Carolina Jancic, PhD

Independent investigator CONICET

📧 cjancic@gmail.com

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Jeremías G Galletti, PhD

Clinical associated investigator CONICET, Welcome International Intermediate Fellow, Fulbright Visiting Scholar

📧 jeremiasg@gmx.net

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Florencia Sabbione, PhD

Assistant investigator CONICET

📧 florsabb@gmail.com

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• Dr. Irene Keitelman (Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires):
  Postdoctoral Fellow, Academia Nacional de Medicina.
  Admission to CIC CONICET approved in 2023; appointment not yet formalized.
  Supervisor: Analía Trevani.
• Micaela Rosato: Doctoral Fellow, CONICET. Supervisor: Carolina Jancic.
• Manuela Pizzano: Doctoral Fellow, CONICET. Supervisor: Jeremías Galletti.
• Douglas Vera Aguilar: Doctoral Completion Fellow, Academia Nacional de Medicina. Supervisor: Analía Trevani.
• Polina Dzvonyk: Doctoral Fellow, CONICET. Supervisor: Jeremías Galletti.
• Maia Jazmín Martínez: Initial Fellow, Agencia I+D+i. Supervisor: Jeremías Galletti.
• Juliana Bernatowiez: Research Fellow, Wellcome. Supervisor: Jeremías Galletti.

Our research is focused on two thematic axes:

1. To identify factors able to induce neutrophil activation or death, and the study of mechanisms that control various responses mediated by these cells.
2. To study mechanisms that regulate the function of γδ T lymphocytes and how these cells interact with neutrophils.

To study the molecular mechanisms involved in the export of IL-1 beta from neutrophils.

Our objective is to elucidate the processes that lead to the release of IL-1 beta to identify potential pharmacological targets to modulate its secretion in inflammatory processes in which IL-1 beta secreted by neutrophils plays a relevant role.

To determine the role of neutrophils in infection induced by Respiratory Syncytial Virus.

In particular, we are interested in elucidating the impact of NETs on infection and the immune response to the virus.

To determine the impact of hyperthermia within the febrile range on the development of inflammatory processes, focusing on regulating the effector functions of neutrophils.

To study the immunomodulatory properties of neutrophils, analyzing the regulation of the functionality of γδ T cells.

This line of work aims to elucidate the mechanisms through which neutrophils regulate the functionality of γδ T cells activated by various stimuli. It is also our interest to evaluate the action of γδ T cells on neutrophils, analyzing the type of response that they initiate after stimulation by γδ T cells.

1. Pizzano M, Vereertbrugghen A, Martinez J, Bernatowiez J, Vera Aguilar D, Sabbione F, Keitelman I, Fuentes F, Giordano M, Trevani A, Galletti J. A transient receptor potential vanilloid 1-dependent corneal-trigeminal neuroinflammatory circuit promotes corneal neuropathy. Exp Mol Med. 2025 Nov (in press).
2. Jancic CC. γδ T cells in Escherichia coli infection. Int Rev Cell Mol Biol. 2025;398:151-184. PMID: 41161890.
3. Vereertbrugghen A, Pizzano M, Cernutto A, Sabbione F, Keitelman IA, Aguilar DV, Podhorzer A, Fuentes F, Corral-Vázquez C, Guzmán M, Giordano MN, Trevani A, de Paiva CS, Galletti JG. CD4+ T cells drive corneal nerve damage but not epitheliopathy in an acute aqueous-deficient dry eye model. Proc Natl Acad Sci U S A. 2024 Nov 26;121(48):e2407648121.
4. Vereertbrugghen A, Pizzano M, Sabbione F, Del Papa MS, Rodríguez G, Passerini MS, Galletti JG. Hyaluronate Protects From Benzalkonium Chloride-Induced Ocular Surface Toxicity. Transl Vis Sci Technol. 2024 Oct 1;13(10):31.
5. Pizzano M, Vereertbrugghen A, Cernutto A, Sabbione F, Keitelman IA, Shiromizu CM, Vera Aguilar D, Fuentes F, Giordano MN, Trevani AS, Galletti JG. Transient Receptor Potential Vanilloid-1 Channels Facilitate Axonal Degeneration of Corneal Sensory Nerves in Dry Eye. Am J Pathol. 2024 May;194(5):810-827.
6. Sabbione F, Keitelman IA, Shiromizu CM, Vereertbrugghen A, Vera Aguilar D, Rubatto Birri PN, Pizzano M, Ramos MV, Fuentes F, Saposnik L, Cernutto A, Cassataro J, Jancic CC, Galletti JG, Palermo MS, Trevani AS.Regulation of human neutrophil IL-1β secretion induced by Escherichia coli O157:H7 responsible for hemolytic uremic syndrome. PLoS Pathog. 2023 Dec 21;19(12):e1011877.
7. Luci C, Golub R, Jancic CC. Editorial: Innate lymphoid cells: characterization and classification. Front Immunol. 2023 Nov 24;14:1338463.
8. Galletti JG, Scholand KK, Trujillo-Vargas CM, Haap W, Santos-Ferreira T, Ullmer C, Yu Z, de Paiva CS. Effects of Cathepsin S Inhibition in the Age-Related Dry Eye Phenotype. Invest Ophthalmol Vis Sci. 2023 Aug 1;64(11):7.
9. Vereertbrugghen A, Pizzano M, Sabbione F, Keitelman IA, Shiromizu CM, Aguilar DV, Fuentes F, de Paiva CS, Giordano M, Trevani A, Galletti JG. An ocular Th1 immune response promotes corneal nerve damage independently of the development of corneal epitheliopathy
   . J Neuroinflammation. 2023 May 22;20(1):120.
10. Galletti JG, Scholand KK, Trujillo-Vargas CM, Yu Z, Mauduit O, Delcroix V, Makarenkova HP, de Paiva CS. Ectopic lymphoid structures in the aged lacrimal glands. Clin Immunol. 2023 Mar;248:109251.
11. Keitelman IA, Shiromizu CM, Zgajnar NR, Danielián S, Jancic CC, Martí MA, Fuentes F, Yancoski J, Vera Aguilar D, Rosso DA, Goris V, Buda G, Katsicas MM, Galigniana MD, Galletti JG, Sabbione F, Trevani AS. The interplay between serine proteases and caspase-1 regulates the autophagy-mediated secretion of Interleukin-1 beta in human neutrophils. Front Immunol. 2022 Aug 25;13:832306.
12. Vereertbrugghen A, Galletti JG.Corneal nerves and their role in dry eye pathophysiology. Exp Eye Res. 2022 Sep;222:109191.
13. Rosso DA, Rosato M, Gómez FD, Álvarez RS, Shiromizu CM, Keitelman IA, Ibarra C, Amaral MM, Jancic CC. Human Glomerular Endothelial Cells Treated With Shiga Toxin Type 2 Activate γδ T Lymphocytes
    . Front Cell Infect Microbiol. 2021 Nov 25;11:765941.
14. Rosso DA, Rosato M, Iturrizaga J, González N, Shiromizu CM, Keitelman IA, Coronel JV, Gómez FD, Amaral MM, Rabadan AT, Salamone GV, Jancic CC. Glioblastoma cells potentiate the induction of the Th1-like profile in phosphoantigen-stimulated γδ T lymphocytes. J Neurooncol. 2021 Jul;153(3):403-415.
15. Calo G, Trevani AS, Grasso E, Keitelman IA, Ramhorst R, Leirós CP, Sabbione F. In Vitro Identification and Isolation of Human Neutrophil Extracellular Traps. Methods Mol Biol. 2021;2255:97-117.
16. Galletti JG, de Paiva CS. Age-related changes in ocular mucosal tolerance: Lessons learned from gut and respiratory tract immunity
    . Immunology. 2021 Sep;164(1):43-56.
17. Galletti JG, de Paiva CS. The ocular surface immune system through the eyes of aging. Ocul Surf. 2021 Apr;20:139-162.
18. Pellegrini JM, Sabbione F, Morelli MP, Tateosian NL, Castello FA, Amiano NO, Palmero D, Levi A, Ciallella L, Colombo MI, Trevani AS, García VE. Neutrophil autophagy during human active tuberculosis is modulated by SLAMF1. Autophagy. 2021 Sep;17(9):2629-2638.
19. Guzmán M, Miglio M, Keitelman I, Shiromizu CM, Sabbione F, Fuentes F, Trevani AS, Giordano MN, Galletti JG. Transient tear hyperosmolarity disrupts the neuroimmune homeostasis of the ocular surface and facilitates dry eye onset. Immunology. 2020 Oct;161(2):148-161.
20. Keitelman IA, Sabbione F, Shiromizu CM, Giai C, Fuentes F, Rosso D, Ledo C, Miglio Rodriguez M, Guzman M, Geffner JR, Galletti J, Jancic C, Gómez MI, Trevani AS. Short-Term Fever-Range Hyperthermia Accelerates NETosis and Reduces Pro-inflammatory Cytokine Secretion by Human Neutrophils. Front Immunol. 2019 Oct 18;10:2374.
21. Shiromizu CM, Jancic CC. γδ T Lymphocytes: An Effector Cell in Autoimmunity and Infection. Front Immunol. 2018 Oct 16;9:2389.
22. Guzmán M, Miglio MS, Zgajnar NR, Colado A, Almejún MB, Keitelman IA, Sabbione F, Fuentes F, Trevani AS, Giordano MN, Galletti JG. The mucosal surfaces of both eyes are immunologically linked by a neurogenic inflammatory reflex involving TRPV1 and substance P. Mucosal Immunol. 2018 Sep;11(5):1441-1453.
23. Iula L, Keitelman IA, Sabbione F, Fuentes F, Guzman M, Galletti JG, Gerber PP, Ostrowski M, Geffner JR, Jancic CC, Trevani AS. Autophagy Mediates Interleukin-1β Secretion in Human Neutrophils. Front Immunol. 2018 Feb 19;9:269.
24. Towstyka NY, Shiromizu CM, Keitelman I, Sabbione F, Salamone GV, Geffner JR, Trevani AS, Jancic CC. Modulation of γδ T-cell activation by neutrophil elastase. Immunology. 2018 Feb;153(2):225-237.
25. Sabbione F, Keitelman IA, Iula L, Ferrero M, Giordano MN, Baldi P, Rumbo M, Jancic C, Trevani AS. Neutrophil Extracellular Traps Stimulate Proinflammatory Responses in Human Airway Epithelial Cells. J Innate Immun. 2017;9(4):387-402.
26. Galletti JG, Guzmán M, Giordano MN. Mucosal immune tolerance at the ocular surface in health and disease. Immunology. 2017 Apr;150(4):397-407.
27. Guzmán M, Keitelman I, Sabbione F, Trevani AS, Giordano MN, Galletti JG. Mucosal tolerance disruption favors disease progression in an extraorbital lacrimal gland excision model of murine dry eye. Exp Eye Res. 2016 Oct;151:19-22.
28. Ramos MV, Mejias MP, Sabbione F, Fernandez-Brando RJ, Santiago AP, Amaral MM, Exeni R, Trevani AS, Palermo MS. Induction of Neutrophil Extracellular Traps in Shiga Toxin-Associated Hemolytic Uremic Syndrome. J Innate Immun. 2016;8(4):400-11.
29. Guzmán M, Keitelman I, Sabbione F, Trevani AS, Giordano MN, Galletti JG.Desiccating stress-induced disruption of ocular surface immune tolerance drives dry eye disease. Clin Exp Immunol. 2016 May;184(2):248-56.
30. Galletti JD, Ruiseñor Vázquez PR, Fuentes Bonthoux F, Pförtner T, Galletti JG. Multivariate Analysis of the Ocular Response Analyzer’s Corneal Deformation Response Curve for Early Keratoconus Detection. J Ophthalmol. 2015;2015:496382.
31. Galletti JD, Ruiseñor Vázquez PR, Minguez N, Delrivo M, Bonthoux FF, Pförtner T, Galletti JG. Corneal asymmetry analysis by pentacam scheimpflug tomography for keratoconus diagnosis. J Refract Surg. 2015 Feb;31(2):116-23.