PATHOGENESIS OF VIRAL INFECTION
The focus of our laboratory is the study of human viral infections and includes the study of the infectious agent, its detection and diagnosis and the processes in the host. We also investigate different viral, immunological or genetic factors that may be associated with the clinical presentation of the disease. We demonstrated the existence of replication of Hepatitis C virus (HCV) in mononuclear cell cultures and cell lines and studied the genotypes associated with this site, highlighting its importance as a viral reservoir. We evaluated different clinical, virological, immunological and genetic aspects that could have an impact on the progression of human immunodeficiency virus and the hepatitis C virus coinfection (HIV-HCV). We have conducted studies evaluating the persistence of humoral and cellular immune memory in vaccinated individuals. Currently, our research projects are mainly focused on studies of the dengue virus and SARS-CoV-2. We maintain collaborations with different institutions and laboratories that include the CEBAC laboratory of Posadas, Misiones, with the virology laboratory of the Facultad de Farmacia y Bioquímica (UBA) and the Infectious Diseases Laboratory of the National Institutes of Health of the United States (NIH)). We develop and apply cell culture, molecular biology and immunology techniques to study different aspects of the pathogenesis of different viral infections.
Chair: Patricia Baré, PhD – CONICET Independent researcher.
Email: patobare@gmail.com