- Antigen-presenting cells and inflammatory response
- Pharmacogenomics
- Physiology of Inflammatory processes
- Experimental Oncology
- Genetics of Lymphoid Malignancies
- Hematological genetics
- Molecular Genetics of Hemophilia
- Haemostasis and thrombosis
- Immunology of Respiratory Diseases
- Experimental immunology
- Innate immunity
- Onco-immunology
- Mutagenesis
- Pathogenesis and inmunology of infectious processes
- Pathogenesis of viral infections
- Trombosis Experimental e Inmunobiología de la Inflamación
ANTIGEN-PRESENTING CELLS AND INFLAMMATORY RESPONSE
Dendritic cells (DCs) as professional antigen presenting cells represent the link between a variety of non-self-antigens and adaptive immunity, orchestrating the quality and potency of immune responses. Considering the main role of DCs in the generation and/or regulation of the adaptive response, it is important to know the stimuli and/or signals involved in the modulation of its functionality.
The main axis of our work group is to try to understand the mechanisms involved during the activation of DCs that allow the polarization of responses of purely inflammatory etiology associated with the development of CD4+ (Th1/Th17/Th2) and/or CD8 (Tc1 /Tc2/Tc17). The interest of our findings is not only related to understanding the physiology of DCs, but also to the mechanisms that determine the immune/immunopathological balance. Particularly, in 3 central aspects;
1. The close relationship between mast cells and antigen presenting cells (APC; DCs, Macrophages) at the epithelial level of the skin and mucous membranes,
2. The high incidence of inflammatory pathologies with elevated levels of lipid mediators and histamine and/or their receptors and
3. The important immunomodulatory role of the autonomic nervous system, and the great relevance it has acquired in recent years at the level of the induction of pathologies of inflammatory etiology such as asthma and neoplastic processes.
Chair: Mónica Vermeulen, PhD.
CONICET Independent researcher
Email: mvermeulen@hematologia.anm.edu.ar
Co-Chair: Gabriela Salamone, PhD.
CONICET Independent reseacher
Email: salamone.gabriela@gmail.com
Ramiro Vázquez, PhD. CONICET Assistant researcher. Supervisor: M. Vermeulen.
Email: ramirobioq@gmail.comVermeulen
- Alejandra Infante de la Cruz, MSc. PhD student – CONICET. Supervisor: G. Salamone.
- Paula Saibene Vélez, BCs. PhD student – Agencia. Supervisor: G. Salamone.
Joaquín Rosato. Medical student. Supervisor: M. Vermeulen.
- ‘Mechanisms involved in the induction of unconventional CD8 lymphocyte responses by histamine. Role of antigen presenting cells’. Responsible Dr. Monica Vermeulen
- ‘Role of inflammatory mediators in the development of pathologies that affect the intestinal mucosa’. Responsible Dr. Monica Vermeulen
- ‘Influence of the non-neuronal Cholinergic System in the pathogenesis of glioblastoma and its impact on the immune response’ Dr. Gabriela Salamone
- ‘Relevance of TSLP (thymic stromal lymphopoietin) in the pathophysiology of brain tumors’. Dr. Gabriela Salamone
- Towstyka NY, Shiromizu CM, Keitelman I, Sabbione F, Salamone GV, Geffner JR, Trevani AS, Jancic CC. Modulation of γδ T-cell activation by neutrophil elastase. Immunology. 2018 Feb;153(2):225-237.
- Chiarella P, Vermeulen M, Montagna DR, Vallecorsa P, Strazza AR,Meiss RP, Bustuoabad OD, Ruggiero RA, Prehn RT. Improvement of Antitumor Therapies Based on Vaccines and Immune-Checkpoint Inhibitors by Counteracting Tumor-Immunostimulation. Front Oncol. 2018 Jan 26;8:6.
- Parra FL, Caimi AT, Altube MJ, Cargnelutti DE, Vermeulen ME, de Farias MA, Portugal RV, Morilla MJ, Romero EL. Make It Simple: (SR-A1+TLR7) Macrophage Targeted NANOarchaeosomes. Front Bioeng Biotechnol. 2018;6:163.
- Gori S, Alcain J, Vanzulli S, Moreno Ayala MA, Candolfi M, Jancic C, Geffner J, Vermeulen M, Salamone G. Acetylcholine-treated murine dendritic cells promote inflammatory lung injury. PLoS One. 2019;14(3):e0212911.
- Gori S, Alcain J, Vanzulli S, Moreno Ayala MA, Candolfi M, Jancic C, Geffner J, Vermeulen M, Salamone G. Acetylcholine-treated murine dendritic cells promote inflammatory lung injury. PLoS One. 2019 Mar 1;14(3):e0212911.
- Soczewski E, Gori S, Paparini D, Grasso E, Fernández L, Gallino L, Schafir A, Irigoyen M, Lobo TF, Salamone G, Mattar R, Daher S, Pérez Leirós C, Ramhorst R. VIP conditions human endometrial receptivity by privileging endoplasmic reticulum stress through ATF6α pathway. Mol Cell Endocrinol. 2020 Oct 1;516:110948.
- Gori S, Soczewski E, Fernández L, Grasso E, Gallino L, Merech F, Colado A, Borge M, Pérez Leirós C, Salamone G, Ramhorst R. Decidualization Process Induces Maternal Monocytes to Tolerogenic IL-10-Producing Dendritic Cells.Front Immunol. 2020 Aug 18;11:1571.
- Langellotti, C A. Gammella, Mariela, Soria I, Bellusci, C, Quattrocchi, V, Vermeulen M, Mongini, C, Zamorano P. An Improved DNA Vaccine Against Bovine Herpesvirus-1 Using CD40L and a Chemical Adjuvant Induces Specific Cytotoxicity in Mice. Viral Immunol. 2020,34(2):68-78.
- Leite-de-Moraes M., Chieppa M, Vermeulen M. Innate Immune Cells and Inflammatory Mediators in Mucosal Pathologies. Frontiers Immunology 2020,11:1679.
- Valentín Coronel, Vanina A Fontana, Alcain Julieta, Vermeulen M, Salamone G. Update on the Functionality of Thymic Stromal Lymphopoietin and its Interaction with Dendritic Cells, to Trigger a Pro or Anti-Inflammatory Status. J. Allergy Research 2021.
- Pappalardo, Juan Sebastian, Salmaso, Stefano, Levchenko, Tatyana S., Mastrotto, Francesca, Bersani, Sara, Langellotti, Cecilia A., Vermeulen M, Zamorano, Patricia I., Hartner, William C. Toniutti, Micaela, Musacchio, Tiziana, Torchilin, Vladimir P. Characterization of a Nanovaccine Platform Based on an α1,2-Mannobiose Derivative Shows Species-non-specific Targeting to Human, Bovine, Mouse, and Teleost Fish Dendritic Cells. Molecular Pharmaceutics 2021, 18(7):2540-2555.
- Bernal AM, Fernández-Brando RJ, Bruballa AC, Fiorentino GA, Pineda GE, Zotta E, Vermeulen M, Ramos MV, Rumbo M, Palermo MS. Differential Outcome between BALB/c and C57BL/6 Mice after Escherichia coli O157:H7 Infection Is Associated with a Dissimilar Tolerance Mechanism. Infect Immun. 2021 Apr 16;89(5):e00031-21.
- Gamba JC, Roldán C, Prochetto E, Lupi G, Bontempi I, Poncini CV, Vermeulen M, Pérez AR, Marcipar I, Cabrera G. Targeting Myeloid-Derived Suppressor Cells to Enhance a Trans-Sialidase-Based Vaccine Against Trypanosoma cruzi. Front Cell Infect Microbiol. 2021 Jul 6;11:671104.
- Alcain J, Infante Cruz ADP, Barrientos G, Vanzulli S, Salamone G,Vermeulen M. Mechanisms of unconventional CD8 Tc2 lymphocyte induction in allergic contact dermatitis: Role of H3/H4 histamine receptors. Front Immunol. 2022 Oct 7;13:999852.
- Sánchez-León ML, Jiménez-Cortegana C, Cabrera G, Vermeulen EM, de la Cruz-Merino L, Sánchez-Margalet V. The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells. Front Immunol. 2022 Nov 15;13:1050484.
- Leite-de-Moraes M, Chieppa M, Vermeulen M. Editorial: Immune cells and inflammatory mediators in mucosal pathologies, volume II. Front Immunol. 2022 Dec 6;13:1092146.
- Cambiasso MY, Gotfryd L, Stinson MG, Birolo S, Salamone G, Romanato M, Calvo JC, Fontana VA. Paternal alcohol consumption has intergenerational consequences in male offspring. J Assist Reprod Genet. 2022 Feb;39(2):441-459. doi: 10.1007/s10815-021-02373-0
Mónica Vermeulen. Editor, Research Topic: Immune cells and inflammatory mediators in mucosal pathologies, Frontiers Immunology, since 2020.
Gabriela Salamone y Mónica Vermeulen. Head of practical assignments in ‘Inmunología’, Facultad de Medicina, UBA.