EXPERIMENTAL THROMBOSIS AND IMMUNOBIOLOGY OF INFLAMMATION
The Laboratory of Experimental Thrombosis and Inflammation Immunobiology investigates the cellular and molecular mechanisms involved in the pathophysiology of thrombosis and in chronic and autoimmune inflammatory processes. Its main goal is to understand how these phenomena originate and are regulated, generating knowledge that contributes to the development of new therapeutic strategies.
One line of research focuses on studying the interaction between innate immune cells, platelets, and the endothelium. This approach allows the analysis of activation and communication mechanisms among these key cells, which are fundamental to both physiological hemostasis and pathological thromboinflammation.
Another research line centers on the generation of megakaryocytes and platelets under inflammatory or infectious conditions, using an in vitro model derived from human umbilical cord blood stem cells. This work aims to understand how different contexts influence platelet production and the differentiation of megakaryocytes with an immune phenotype.
The laboratory also investigates the differentiation and function of the monocyte/macrophage lineage, known for its high functional plasticity. This capacity enables these cells to integrate multiple environmental signals and adapt to various scenarios such as inflammation, tissue repair, or infection.
Overall, the laboratory seeks to unravel the links among inflammation, thrombosis, and immunity—three closely interconnected processes that contribute to the onset and progression of diverse human diseases.
